| 1. | Different mhc molecules fight different diseases , so it s important to have a mix
分子与不同的疾病斗争，因此，不同分子的组合是非常重要的。 |
| 2. | Females use smell to identify partners with suitable mhc molecules : choosing only males with the correct mix of immune genes critical for the survival of future offspring
分子的伴侣，这样一来，它仅仅选择那些对后代的存活至关重要的、具有正确免疫基因组合的雄性动物。 |
| 3. | In the experiment females were fooled by the protein fragments into believing that males with insufficient mhc molecules would provide offspring with the ideal number of mhc types
在试验中，雌性动物受到分子碎片的愚弄，使得它们相信那些具有不充足mhc分子的雄性动物会产生出具有理想类型mhc的后代。 |
| 4. | However , when the perfume was added to males that already had the ideal range of mhc molecules , females could also be fooled into believing that these males smelled repulsive : having too many immune genes for offspring
然而，当为那些已经具有充足mhc的雄性动物涂抹上香水后，雌性动物会误以为这些雄性动物很难闻：对于后代而言，它们具有过多的免疫基因。 |
| 5. | Covers cells and tissues of the immune system , lymphocyte development , the structure and function of antigen receptors , the cell biology of antigen processing and presentation including molecular structure and assembly of mhc molecules , the biology of cytokines , leukocyte - endothelial interactions , and the pathogenesis of immunologically mediated diseases
课程涵盖免疫系统的细胞和组织，淋巴球的发育过程，抗原受体的结构和功能，抗原反应过程的细胞生物学以及抗原的呈现，其中包括mhc分子的结构与组合，细胞激素的生物学，白血球和内皮组织的互动关系，以及免疫相关疾病的致病机转。 |
| 6. | Then we conducted in vitro gene transfer , transfecting p388d1 with recombinant eukaryotic vector and infecting hela with recombinant adenoviruses respectively , in order to observe inhibition of constitutive or inducible cii ta gene expression by introduced complementary antisense rna of c iita and consequent do wnregulation of class ii mhc molecules expression
结果显示：含反义c ta的真核表达载体转染组成型mhc -类分子表达p388d1细胞株，经抗生素抗性筛选后表达mhc -类分子的细胞阳性率比对照组下降65 |
| 7. | Dcs play a pivotal role in the development of antitumor immunity . t lymphocytes immune response induced by direct antigen - pulsed dcs can not maintain longer for peptides - mhc department or mhc molecules degeneration . the method of dcs loading with tumor antigen gene is another potential approach to enhancing and maintaining immune response
在用抗原直接刺激dc时，由于抗原- mhc复合物解离或细胞mhc分子降解而不能维持所诱导的t细胞免疫应答，借助载体把肿瘤抗原基因导入dc后肿瘤抗原在dc内的持续表达能增强其抗原提呈能力并能维持所诱导的免疫效应。 |
| 8. | The results of inhibition of t cells activation assay indicated that activation of t lymphocytes which mainly recognize the different compatibility of class ii mhc molecules was inhibited in different degree due to the inhibited inducible expression of class ii mhc molecules on hela by recombinant adenoviruses containi ng cii ta antisense fragment , showing as decreases in the positive rate and mean fluorescent intensity of cd25 and cd69 expression , which are both signs of activated t cells
T细胞激活抑制实验表明：由于重组腺病毒携带的反义c11ta片段，不同程度地抑制了hela细胞诱导型mhc二类分子的表达，使主要识别mhc 11类分子相容性不同的t淋巴细胞活化受到不同程度的抑制，表现为t细胞激活标记物cd25和cd69表达的阳性率和平均荧光强度均下降，其中一例cd25阳性率降低17 l ，平均荧光强度降低50 |
